Background Image Background Image

Single-Molecule NanoAnalyzer

Redefining sensitivity with advanced single-photon counting module, designed to detect individual drug payloads and particle markers with precision.

EV analytical accuracy with unmatched sensitivity and lowest background

  • EV size, concentration, and biomarkers—all in a single run

  • Contaminant detection and purification assessment

  • Epitope mapping and drug loading optimization

Test the Integrity and Performance of your Viral Vector biotherapeutics with confidence

  • Size and concentration

  • Vector loading ratio

  • Multiparameter component analysis

  • Evaluate vector integrity

  • Enumerate functional vectors from empty capsi

Optimize formulation and delivery performance of mRNA-LNPs

  • Size and concentration

  • Loading ratio and encapsulation efficiency

  • mRNA distribution and surface ligand analysis

Ensuring efficacy and consistency of EV-based vaccines

  • Size and concentration

  • Empty / Full ratio

  • Antigen quantification

  • Stability tracking

Single-Molecule NanoAnalyzer
EV analytical accuracy with unmatched sensitivity and lowest background
Test the Integrity and Performance of  your Viral Vector biotherapeutics with confidence
Optimize formulation and delivery performance of mRNA-LNPs
Ensuring efficacy and consistency of EV-based vaccines
team_img
team_img
team_img
team_img
team_img
team_img
team_img
team_img
team_img
team_img
team_img
team_img
team_img

外泌体/细胞外囊泡

THE ORIGIN AND PHENOTYPING OF EXTRACELLULAR VESICLES

team_img

病毒/病毒疫苗

TRULY QUANTITATIVE MEASUREMENT OF TOTAL TITER AND SUBGROUP TITER OF VIRUS

team_img

纳米药物

COMPREHENSIVE MEASUREMENT SUITE FOR NANOSIZED DRUG PRODUCTS

team_img

细菌检测

TRULY QUANTITATIVE MEASUREMENT OF TOTAL BACTERIAL TITRE

team_img

疫苗

COMPREHENSIVE CHARACTERIZATION PLATFORM FOR VACCINE

team_img

其他类型

COMPREHENSIVE MEASUREMENT SUITE FOR NANOPARTICLES AND INDIVIDUAL MITOCHONDRIA

team_img

外泌体/细胞外囊泡

THE ORIGIN AND PHENOTYPING OF EXTRACELLULAR VESICLES

DETAILS
team_img

病毒/病毒疫苗

TRULY QUANTITATIVE MEASUREMENT OF TOTAL TITER AND SUBGROUP TITER OF VIRUS

DETAILS
team_img

纳米药物

COMPREHENSIVE MEASUREMENT SUITE FOR NANOSIZED DRUG PRODUCTS

DETAILS
team_img

细菌检测

TRULY QUANTITATIVE MEASUREMENT OF TOTAL BACTERIAL TITRE

DETAILS
team_img

疫苗

COMPREHENSIVE CHARACTERIZATION PLATFORM FOR VACCINE

DETAILS
team_img

其他类型

COMPREHENSIVE MEASUREMENT SUITE FOR NANOPARTICLES AND INDIVIDUAL MITOCHONDRIA

DETAILS
team_img

外泌体/细胞外囊泡

THE ORIGIN AND PHENOTYPING OF EXTRACELLULAR VESICLES

team_img

病毒/病毒疫苗

TRULY QUANTITATIVE MEASUREMENT OF TOTAL TITER AND SUBGROUP TITER OF VIRUS

team_img

纳米药物

COMPREHENSIVE MEASUREMENT SUITE FOR NANOSIZED DRUG PRODUCTS

team_img

细菌检测

TRULY QUANTITATIVE MEASUREMENT OF TOTAL BACTERIAL TITRE

team_img

疫苗

COMPREHENSIVE CHARACTERIZATION PLATFORM FOR VACCINE

team_img

其他类型

COMPREHENSIVE MEASUREMENT SUITE FOR NANOPARTICLES AND INDIVIDUAL MITOCHONDRIA

Nano-flow cytometry’s ability to measure simultaneously a (bio)-nanoparticle population for size, size distribution and bio-chemical properties on a single instrument dramatically improves data quality and throughput compared to the traditional, multiple-techniques approach involving particle characterisation and counting (DLS, NTA, RPS), combined with chemical and biological function assessment (ELISA, Western Blot, Flow Cytometry, PCR). Quantitative measurement of the active and contaminant particles in a single preparation opens up the possibility of characterisation-based nanomedicine regulatory approval, and allows the conduct of large-scale clinical studies. From the research laboratory to the quality control department, NanoFCM delivers comprehensive bio-nano analysis.

NanoFCM has developed the NanoAnalyzer platform that now enables true flow-cytometry measurement at the sub-micron scale, and down to particle sizes unreachable by any other flow cytometers (10-40nm depending on the nature of the substrate). Nano-flow cytometry, the technology that underpins the NanoAnalyzer, removes bias and uncertainty stemming from the use of fluorescence signal triggering by using its highly sensitive side-scatter channel to trigger particle events. The single-particle nature of the measurement prevents uncontrolled swarming events, reinforcing data integrity. High resolution of both scatter and fluorescence channels allows the assessment of subpopulations, based on size or on bio-chemical properties.

For many years scientists yearned for the possibility of performing flow cytometry to analyse small bio-nanoparticles that are too small to be measured by conventional and high sensitivity instruments. These entities, extracellular vesicles, gene therapy vectors, viruses and drug delivery particles, are promised to become the next generation of therapeutics, but they have been hard to handle and characterise due to their small size and biological or chemical heterogeneity. There is therefore a strong case for bringing flow cytometry capability to the sub-200nm scale.